Potentiation of HIV-1 Expression in Microglial Cells by Nicotine: Involvement of Transforming Growth Factor-β1

@article{Rock2007PotentiationOH,
  title={Potentiation of HIV-1 Expression in Microglial Cells by Nicotine: Involvement of Transforming Growth Factor-β1},
  author={Robert Bryan Rock and Genya Gekker and Rajagopal N Aravalli and Shuxian Hu and Wen Sheng and Phillip K. Peterson},
  journal={Journal of Neuroimmune Pharmacology},
  year={2007},
  volume={3},
  pages={143-149}
}
HIV-1 infection and nicotine addiction are global public health crises. In the central nervous system, HIV-1 causes a devastating neurodegenerative disease. It is well recognized that microglial cells play a pivotal role in the neuropathogenesis of HIV-1 and that drugs of abuse not only contribute to the spread of this agent but may facilitate viral expression in these brain macrophages. Nicotine has been shown to stimulate the production of HIV-1 by in vitro-infected alveolar macrophages, and… CONTINUE READING

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