Potentiation of Evoked Vesicle Turnover at Individually Resolved Synaptic Boutons

@article{Ryan1996PotentiationOE,
  title={Potentiation of Evoked Vesicle Turnover at Individually Resolved Synaptic Boutons},
  author={T. A. Ryan and N. Ziv and Stephen J. Smith},
  journal={Neuron},
  year={1996},
  volume={17},
  pages={125-134}
}
We have studied synaptic plasticity in hippocampal cell cultures using a new imaging approach that allows unambiguous discrimination of presynaptic function at the level of single synaptic boutons. Employing a protocol designed to test for use-dependent plasticity resembling N-methyl-D-aspartate receptor-dependent long-term potentiation (NMDA-type LTP), we find that brief tetanic stimuli induce a potentiation of evoked synaptic vesicle turnover that lasts for at least 1 hr. Induction of this… Expand
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