Potentiation of Ca(2+) release by cADP-ribose in the heart is mediated by enhanced SR Ca(2+) uptake into the sarcoplasmic reticulum.

@article{Lukyanenko2001PotentiationOC,
  title={Potentiation of Ca(2+) release by cADP-ribose in the heart is mediated by enhanced SR Ca(2+) uptake into the sarcoplasmic reticulum.},
  author={Valeriy Lukyanenko and Inna Gy{\"o}rke and Theodore F Wiesner and S{\'a}ndor Gy{\"o}rke},
  journal={Circulation research},
  year={2001},
  volume={89 7},
  pages={614-22}
}
cADP-Ribose (cADPR) is a novel endogenous messenger that is believed to mobilize Ca(2+) from ryanodine-sensitive Ca(2+) stores. Despite intense research, the precise mechanism of action of cADPR remains uncertain, and experimental findings are contradictory. To elucidate the mechanism of cADPR action, we performed confocal Ca(2+) imaging in saponin-permeabilized rat ventricular myocytes. Exposure of the cells to cADPR resulted in a slow (>2 minutes) and steady increase in the frequency of Ca(2… CONTINUE READING

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Ca 21 sparks and Ca 21 waves in saponin-per meabilized cardiac myocytes

  • V Lukyanenko, S. Györke
  • J Physiol (Lond)
  • 1999

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