Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems.

@article{Nadeson2002PotentiationBK,
  title={Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems.},
  author={Ray Nadeson and Adam Paul Tucker and E Bajunaki and Colin S. Goodchild},
  journal={British journal of anaesthesia},
  year={2002},
  volume={88 5},
  pages={685-91}
}
BACKGROUND Ketamine has been found to exert antinociceptive effects in animals and to be analgesic at subanaesthetic doses in humans. This study was designed to investigate the involvement of spinal cord mechanisms in the potentiation of opioid analgesia by parenteral non-spinal administration of ketamine. METHODS Thresholds for nociception were measured in an acute pain model in rats that allowed identification of antinociceptive effects due to drug action in the spinal cord. Dose-response… CONTINUE READING

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