Potentiation by insulin and insulin-like growth factor-1 of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.

@article{Sakuta1994PotentiationBI,
  title={Potentiation by insulin and insulin-like growth factor-1 of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.},
  author={Hitoshi Sakuta},
  journal={European journal of pharmacology},
  year={1994},
  volume={268 3},
  pages={
          375-80
        }
}
Effects of insulin and IGF-1 (insulin-like growth factor-1) on K+ channel opener-induced/glibenclamide-sensitive K+ currents were studied using follicle-enclosed Xenopus oocytes. Both insulin (4 x 10(-9)-4 x 10(-6) M) and IGF-1 (4 x 10(-10)-4 x 10(-7) M) increased the cromakalim-induced K+ currents in a concentration-dependent manner. The current-facilitating effect of IGF-1 was about ten times as potent as that of insulin. Treatment of the oocyte with pertussis toxin (2 micrograms/ml… CONTINUE READING
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