Potentiation by WIN 55,212-2 of GABA-activated currents in rat trigeminal ganglion neurones.

@article{Li2009PotentiationBW,
  title={Potentiation by WIN 55,212-2 of GABA-activated currents in rat trigeminal ganglion neurones.},
  author={Zhi-wang Li and Jian Wei Zhang and Chang-han Ouyang and Chao-ying Li and Feng-bo Zhao and Yu-wei Liu and Yong-xun Ai and Wang-Ping Hu},
  journal={British journal of pharmacology},
  year={2009},
  volume={158 8},
  pages={1904-10}
}
BACKGROUND AND PURPOSE Although both natural and synthetic cannabinoid compounds have been shown to exert an antinociceptive effect on acute and persistent pain, the anatomical locus of the target of cannabinoid-induced analgesia has not been fully elucidated. Here, we investigated the effects of the cannabinoid agonist WIN 55,212-2 on GABA-activated currents (I(GABA)) in rat primary sensory neurones. EXPERIMENTAL APPROACH In the present study, experiments were performed on neurones freshly… CONTINUE READING