Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation.

@article{Russo1985PotentiationAP,
  title={Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation.},
  author={Angelo Russo and James B. Mitchell},
  journal={Cancer treatment reports},
  year={1985},
  volume={69 11},
  pages={1293-6}
}
One of the proposed mechanisms of doxorubicin cytotoxicity is generation of activated oxygen species, all of which are either free radical or potentially free radical species. Glutathione is an intracellular sulfhydryl-containing tripeptide that is known to detoxify free radicals and the damage they produce. The cytotoxicity of doxorubicin was evaluated… CONTINUE READING