Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

  title={Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism},
  author={Wei Yang and Yibing Bai and Ying Xiong and Jin Zhang and Shuokai Chen and Xiaojun Zheng and Xiangbo Meng and Lunyi Li and Jing Wang and Chenguang Xu and Chengsong Yan and Lijuan Wang and Catharine C. Y. Chang and T. Y. P. Chang and Ti Zhang and Penghui Zhou and Bao-Liang Song and Wanli Liu and S Sun and Xiaolong Liu and Boliang Li and Chenqi Xu},
CD8+ T cells have a central role in antitumour immunity, but their activity is suppressed in the tumour microenvironment. Reactivating the cytotoxicity of CD8+ T cells is of great clinical interest in cancer immunotherapy. Here we report a new mechanism by which the antitumour response of mouse CD8+ T cells can be potentiated by modulating cholesterol metabolism. Inhibiting cholesterol esterification in T cells by genetic ablation or pharmacological inhibition of ACAT1, a key cholesterol… CONTINUE READING
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