Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia.

@article{Crazzolara2009PotentiatingEO,
  title={Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia.},
  author={Roman Crazzolara and Adam Cisterne and Marilyn Thien and John Hewson and Rana Baraz and Kenneth F. Bradstock and Linda J Bendall},
  journal={Blood},
  year={2009},
  volume={113 14},
  pages={3297-306}
}
Despite advances in the treatment of acute lymphoblastic leukemia (ALL), the majority of children who relapse still die of ALL. Therefore, the development of more potent but less toxic drugs for the treatment of ALL is imperative. We investigated the effects of the mammalian target of rapamycin inhibitor, RAD001 (Everolimus), in a nonobese diabetic/severe combined immunodeficiency model of human childhood B-cell progenitor ALL. RAD001 treatment of established disease increased the median… CONTINUE READING

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