Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia.

@article{Lee2013PotentiatedTA,
  title={Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia.},
  author={Eun Ju Lee and H. Park and H. A. Jeon and Hyo Soo Kim and Mi-Sook Chang},
  journal={Regenerative medicine},
  year={2013},
  volume={8 3},
  pages={283-93}
}
BACKGROUND Human bone marrow-derived mesenchymal stem cells (hMSCs) are advantageous for cell-based therapy to treat ischemic diseases owing to their capacity to secrete various paracrine factors with potent angiogenic activity. MATERIALS & METHODS In this study, we describe a method to increase secreted levels of VEGF and HGF from hMSCs without genetic modification. RESULTS We demonstrated that transplantation of primed hMSCs into ischemic limbs led to significantly greater improvements in… CONTINUE READING
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Hypoxic priming of mESCs accelerates vascularlineage differentiation through HIF 1mediated inverse regulation of Oct 4 and VEGF

  • SW Lee, HK Jeong, JY Lee
  • EMBO Mol . Med .
  • 2012

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