Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment.

@article{Liu2012PotentialsAM,
  title={Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment.},
  author={Xiaoshan Liu and Junyoung Lee and Kyunghee Ji and Shunichi Takeda and Kyungho Choi},
  journal={Toxicology letters},
  year={2012},
  volume={211 1},
  pages={70-6}
}
Genotoxic potentials and the mechanisms of six pharmaceuticals, which are frequently detected in surface water worldwide, were investigated using isogenic chicken DT40 mutant cell lines. These pharmaceuticals include erythromycin, sulfamethazine, sulfathiazole, chlortetracycline, oxytetracycline, and diclofenac. The genotoxic effects of these pharmaceuticals were determined based on growth kinetics of several mutant cell lines. Genotoxic chemicals were expected to decrease the growth kinetics… CONTINUE READING
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Assessment of the potential cytogenotoxicity of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac on the zebra mussel (Dreissena polymorpha)

  • M. arolini, A. Binelli, A. Provini
  • Water Air Soil Pollut
  • 2011

Genotoxic effects in erythrocytes of Oreochromis niloticus exposed to nanogramsperliter concentration of 17 estradiol ( E 2 ) : an assessment using micronucleus test and comet assay

  • M. Takata, M. S. Sasaki, +6 authors S. Takeda
  • Water Air Soil Pollut .
  • 2011

A novel approach using DNA repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants

  • K. H. i, T. Kogame, +4 authors S. Takeda
  • toxicity. Environ. Sci. Technol
  • 2009

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