Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment.

  title={Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment.},
  author={Xiaoshan Liu and Junyoung Lee and Kyunghee Ji and Shunichi Takeda and Kyungho Choi},
  journal={Toxicology letters},
  volume={211 1},
Genotoxic potentials and the mechanisms of six pharmaceuticals, which are frequently detected in surface water worldwide, were investigated using isogenic chicken DT40 mutant cell lines. These pharmaceuticals include erythromycin, sulfamethazine, sulfathiazole, chlortetracycline, oxytetracycline, and diclofenac. The genotoxic effects of these pharmaceuticals were determined based on growth kinetics of several mutant cell lines. Genotoxic chemicals were expected to decrease the growth kinetics… CONTINUE READING
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