Potentially hallucinogenic 5‐hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues

@article{Krkkinen2005PotentiallyH5,
  title={Potentially hallucinogenic 5‐hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues},
  author={J K{\"a}rkk{\"a}inen and T Forsstr{\"o}m and Jarkko Tornaeus and Kristiina W{\"a}h{\"a}l{\"a} and Paula S. Kiuru and Aapo Honkanen and U-H. Stenman and Ursula Turpeinen and Antti Hesso},
  journal={Scandinavian Journal of Clinical and Laboratory Investigation},
  year={2005},
  volume={65},
  pages={189 - 199}
}
Bufotenine and N,N‐dimethyltryptamine (DMT) are hallucinogenic dimethylated indolethylamines (DMIAs) formed from serotonin and tryptamine by the enzyme indolethylamine N‐methyltransferase (INMT) ubiquitously present in non‐neural tissues. In mammals, endogenous bufotenine and DMT have been identified only in human urine. The DMIAs bind effectively to 5HT receptors and their administration causes a variety of autonomic effects, which may reflect their actual physiological function. Endogenous… 
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