Potentially functional polymorphisms in PAK1 are associated with risk of lung cancer in a Chinese population.

@article{Zheng2015PotentiallyFP,
  title={Potentially functional polymorphisms in PAK1 are associated with risk of lung cancer in a Chinese population.},
  author={Mingfeng Zheng and Jia Xian Liu and Meng Zhu and R Yin and Juncheng Dai and Jie Sun and Wei Shen and Yong Ji and Guangfu Jin and Hongxia Ma and Jing Dong and L Xu and Zhibin Hu and Hongbing Shen},
  journal={Cancer medicine},
  year={2015},
  volume={4 11},
  pages={1781-7}
}
P21-activated kinase 1(PAK1) plays an important role in the regulation of cell morphogenesis, motility, mitosis, and angiogenesis and has been implicated with tumorigenesis and tumor progression. We hypothesized that functional polymorphisms in PAK1 gene may modify the risk of lung cancer. We screened four potentially functional polymorphisms (rs2154754, rs3015993, rs7109645, and rs2844337) in PAK1 gene and evaluated the association between the genetic variants and lung cancer risk in a case… CONTINUE READING