Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.

@article{Estus1992PotentiallyAC,
  title={Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.},
  author={S. Estus and T. Golde and T. Kunishita and D. Blades and D. Lowery and M. Eisen and M. Usiak and X. Qu and T. Tabira and B. Greenberg},
  journal={Science},
  year={1992},
  volume={255 5045},
  pages={
          726-8
        }
}
The 39- to 43-amino acid amyloid beta protein (beta AP), which is deposited as amyloid in Alzheimer's disease, is encoded as an internal peptide that begins 99 residues from the carboxyl terminus of a 695- to 770-amino acid glycoprotein referred to as the amyloid beta protein precursor (beta APP). To clarify the processing that produces amyloid, carboxyl-terminal derivatives of the beta APP were analyzed. This analysis showed that the beta APP is normally processed into a complex set of 8- to… Expand
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