Potentially Prebiotic Synthesis of Pyrimidine β‐D‐Ribonucleotides by Photoanomerization/Hydrolysis of α‐D‐Cytidine‐2′‐Phosphate

@article{Powner2008PotentiallyPS,
  title={Potentially Prebiotic Synthesis of Pyrimidine β‐D‐Ribonucleotides by Photoanomerization/Hydrolysis of α‐D‐Cytidine‐2′‐Phosphate},
  author={Matthew W. Powner and J. Sutherland},
  journal={ChemBioChem},
  year={2008},
  volume={9}
}
  • Matthew W. Powner, J. Sutherland
  • Published 2008
  • Chemistry, Medicine
  • ChemBioChem
  • The “RNA world” hypothesis is consistent with RNA’s being a prebiotic product, or the biotic invention of a precursor genetic system. A prebiotically plausible synthesis of ribonucleotides would help to differentiate between these two possibilities by providing strong support for the first, and, as such, is a major goal. The efficient conversion of d-ribose aminooxazoline 1 to ad-cytidine 2, by treatment with cyanoacetylene was demonstrated over 30 years ago (Scheme 1), 3] but has not gained 
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