Potentially Prebiotic Synthesis of Pyrimidine β‐D‐Ribonucleotides by Photoanomerization/Hydrolysis of α‐D‐Cytidine‐2′‐Phosphate

  title={Potentially Prebiotic Synthesis of Pyrimidine β‐D‐Ribonucleotides by Photoanomerization/Hydrolysis of α‐D‐Cytidine‐2′‐Phosphate},
  author={Matthew W. Powner and J. Sutherland},
  • Matthew W. Powner, J. Sutherland
  • Published 2008
  • Chemistry, Medicine
  • ChemBioChem
  • The “RNA world” hypothesis is consistent with RNA’s being a prebiotic product, or the biotic invention of a precursor genetic system. A prebiotically plausible synthesis of ribonucleotides would help to differentiate between these two possibilities by providing strong support for the first, and, as such, is a major goal. The efficient conversion of d-ribose aminooxazoline 1 to ad-cytidine 2, by treatment with cyanoacetylene was demonstrated over 30 years ago (Scheme 1), 3] but has not gained 
    25 Citations

    Topics from this paper.

    A Prebiotic Synthesis of Canonical Pyrimidine and Purine Ribonucleotides
    • 4
    • PDF
    Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water
    • 104
    • PDF
    Exploring the Emergence of RNA Nucleosides and Nucleotides on the Early Earth
    • 9
    • PDF
    227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?
    • 9
    • PDF


    Studies in prebiotic synthesis. V. Synthesis and photoanomerization of pyrimidine nucleosides.
    • 183
    Prebiotic ribose synthesis: A critical analysis
    • R. Shapiro
    • Chemistry
    • Origins of life and evolution of the biosphere
    • 2005
    • 129
    Prebiotic Synthesis: Phosphorylation in Aqueous Solution
    • 112