Potential utility of GB virus type C as a preventive vaccine for HIV-1

@article{Bagasra2012PotentialUO,
  title={Potential utility of GB virus type C as a preventive vaccine for HIV-1},
  author={Omar Bagasra and Alexander U Bagasra and Muhammad Sheraz and Donald Gene Pace},
  journal={Expert Review of Vaccines},
  year={2012},
  volume={11},
  pages={335 - 347}
}
Recent flurries of literature on the beneficial effects of GB virus type C (GBV-C), a hepatitis C-related virus, in HIV-1 coinfected individuals have raised the possibility of its potential use as a preventive vaccine in people with a high risk for HIV-1. However, these findings are still controversial, and the mechanisms contributing to the apparent beneficial effects of GBV-C are still unresolved. Researchers debate whether the beneficial effects of coinfection of GBV-C in HIV-1-infected… 

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TLDR
It has been found that GBV-C viremia has a tendency to disappear over time in HIV-infected subjects who are followed up longitudinally, and this phenomenon, in turn, is associated with accelerated disease progression.

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TLDR
The question whether GBV-C exerts a protective effect in HIV-infected patients remains to be resolved.

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The results highlight that the E2(269-286) sequence interacts with the target fusion peptide of HIV-1 and modifies its conformation, which leads to the development of new therapeutic agents for the treatment of AIDS.

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TLDR
GBV-C infection is common in people with HIV infection and is associated with significantly improved survival, and HIV replication was reproducibly inhibited in cultures of peripheral-blood mononuclear cells by GBV- C coinfection.

Peptides Derived from a Distinct Region of GB Virus C Glycoprotein E2 Mediate Strain-Specific HIV-1 Entry Inhibition

TLDR
Findings reveal a new mechanism of viral interference, suggesting that the envelope protein E2 of GBV-C target directly HIV-1 particles to avoid entry of these virions.

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TLDR
The current knowledge on GB virus C, its role in HIV infection in the HAART era, and the potential mechanisms of its beneficial effect are updated.

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BACKGROUND The flavivirus GB virus C (GBV-C, also designated hepatitis G virus) was identified in a search for hepatitis viruses, but no disease is currently known to be associated with it. We

GB Virus Type C: a Beneficial Infection?

TLDR
Recently, studies found that HIV- positive people who are coinfected with a common, nonpathogenic human flavivirus referred to as GB virus type C (GBV-C) survive significantly longer than do HIV-positive individuals without GBV- C infection.

Effect of synthetic peptides belonging to E2 envelope protein of GB virus C on human immunodeficiency virus type 1 infection.

TLDR
It is shown how GBV-C E2 domains notably decrease cellular membrane fusion and interfere with the HIV-1 infectivity in a dose-dependent manner, highlighting their potential utility in future anti-HIV-1 therapies.
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