Potential use of the comet assay in the clinical management of cancer.

@article{McKenna2008PotentialUO,
  title={Potential use of the comet assay in the clinical management of cancer.},
  author={D. McKenna and S. McKeown and V. McKelvey-Martin},
  journal={Mutagenesis},
  year={2008},
  volume={23 3},
  pages={
          183-90
        }
}
The comet assay has been widely used to measure a range of cellular responses to DNA damage and has found applications in genotoxicity studies, bio-monitoring, ecological testing and in the study of human disease. This review discusses how the comet assay has been applied to the study of DNA damage and repair associated with cancer. The potential of the assay as a tool for predicting an individual's tumour sensitivity to radiation and to various chemotherapeutic drugs is examined, as well as… Expand
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