Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation

@article{Hur2007PotentialUO,
  title={Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation},
  author={Gyu Young Hur and Sung Yong Lee and Seung Hyeun Lee and Se Joong Kim and Kyoung Ju Lee and Jin Yong Jung and Eun Joo Lee and Eun Hae Kang and Ki Hwan Jung and Sang Yeub Lee and Je Hyeong Kim and Chol Shin and Jae Jeong Shim and Kwang Ho In and Kyung Ho Kang and Se Hwa Yoo},
  journal={Experimental & Molecular Medicine},
  year={2007},
  volume={39},
  pages={367-375}
}
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. EGFR has an intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through the signaling kinase cascade in the airway epithelium. We have investigated the effects of an EGFR tyrosine kinase inhibitor, gefitinib, on ovalbumin (OVA)-induced, allergic inflammation in airway epithelia of mice. OVA-sensitized mice were pretreated with gefitinib at two different doses (12.5 and 50… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…