Potential treatment effects of donepezil not detected in Alzheimer's disease clinical trials: a physician survey.

@article{Rockwood2004PotentialTE,
  title={Potential treatment effects of donepezil not detected in Alzheimer's disease clinical trials: a physician survey.},
  author={Kenneth Rockwood and Sandra E. Black and Alain Robillard and Isabelle Lussier},
  journal={International journal of geriatric psychiatry},
  year={2004},
  volume={19 10},
  pages={954-60}
}
OBJECTIVES Clinical trials of the cholinesterase inhibitor donepezil have used standard psychometric tools to evaluate treatment efficacy. These trials, however, appear not to capture clinically demonstrable, but otherwise unmeasured, beneficial treatment effects. We sought to identify and categorize clinically recognizable effects of donepezil treatment in Alzheimer's disease. METHODS A list of potential effects was developed using clinical trials data and the experience of an expert panel… CONTINUE READING

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