Potential therapeutic use of melatonin in migraine and other headache disorders

@article{Peres2006PotentialTU,
  title={Potential therapeutic use of melatonin in migraine and other headache disorders},
  author={M{\'a}rio Fernando Prieto Peres and Marcelo Rodrigues Masruha and Eliova Zukerman and Carlos Alberto Moreira-Filho and Esper Abr{\~a}o Cavalheiro},
  journal={Expert Opinion on Investigational Drugs},
  year={2006},
  volume={15},
  pages={367 - 375}
}
There is increasing evidence that headache disorders are connected with melatonin secretion and pineal function. Some headaches have a clearcut seasonal and circadian pattern, such as cluster and hypnic headaches. Melatonin levels have been found to be decreased in both migraine and cluster headaches. Melatonin mechanisms are related to headache pathophysiology in many ways, including its anti-inflammatory effect, toxic free radical scavenging, reduction of pro-inflammatory cytokine… Expand
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Melatonin in Chronic Pain Syndromes
TLDR
A review of studies of the use of melatonin in fibromyalgia, headaches, irritable bowel syndrome, chronic back pain, and rheumatoid arthritis shows that melatonin has independent analgesic influences mediated via melatonin receptors and various neurotransmitter systems. Expand
[Melatonin in chronic pain syndromes].
TLDR
The authors present a literature review on the studies of melatonin in treatment of fibromyalgia, headache, irritated bowel syndrome, chronic back pain and rheumatoid arthritis and possible mechanisms of analgesic properties are discussed. Expand
Melatonin in Chronic Pain Syndromes
TLDR
The present paper reviews the studies on melatonin use in fibromyalgia, headaches, irritable bowel syndrome, chronic back pain, and rheumatoid arthritis and discusses the possible mechanisms of melatonin analgesic properties. Expand
Therapeutic role of melatonin in migraine prophylaxis
TLDR
Current literature examining melatonin's efficacy in migraine prevention is growing, but still limited, and melatonin is very likely to benefit migraine in prophylaxis and may have a similar effectiveness to other main preventive medications. Expand
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TLDR
Primary headaches are strongly influenced by physiological hormonal fluctuations, when nociceptive and non-nociception pathways are differentially activated to modulate the perception of pain. Expand
Melatonin as a Potential Prophylactic Therapy for Menstrual-Related Migraine Headache: A Randomized Clinical Trial
TLDR
The beneficial role of melatonin was shown in reducing the attack frequency and severity in migraine patients with menstrual-related headaches and preventive therapy with melatonin showed a significant reduction in the number of sedative drug use during attacks and improved the patients’ sleep quality. Expand
Melatonin: functions and ligands.
TLDR
The mechanism of action of melatonin in these disorders is discussed, which could aid in the design of novel melatonin receptor ligands. Expand
A possible new option for migraine management: agomelatine.
TLDR
Agomelatine may be a promising new treatment option for migraine prophylaxis due to its synergistic action on both melatonergic and 5-HT2C receptors. Expand
Future trends in drugs for migraine prophylaxis
TLDR
Drugs designed to inhibit cortical spreading depression, for example tonabersat, might offer a useful option for the management of migraine with aura but not for migraine without aura, and inducible nitric-oxide synthase inhibition seems ineffective as a prophylactic strategy. Expand
Potential use of melatonergic drugs in analgesia: Mechanisms of action
TLDR
Melatonin has a promising role as an analgesic drug that could be used for alleviating pain associated with cancer, headache or surgical procedures and the use of melatonin analogs like the MT(1)/MT(2) agonist ramelteon, which lacks free radical scavenging activity, could be useful to unravel the mechanism of action ofmelatonin in analgesia. Expand
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