Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update

  title={Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update},
  author={Honglei Ren and Ranran Han and Xue-mei Chen and X. Liu and Jieru Wan and L. Wang and Xiuli Yang and J. Wang},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  pages={1752 - 1768}
  • Honglei Ren, Ranran Han, +5 authors J. Wang
  • Published 2020
  • Biology, Medicine
  • Journal of Cerebral Blood Flow & Metabolism
  • Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but no specific or effective treatment. In the last two decades, much has been learned about the pathologic mechanisms of ICH. It is now known that after ICH onset, immune and inflammatory responses contribute to blood–brain barrier disruption, edema development, and cell death processes, jointly resulting in secondary brain injury. However, the translation of potential therapies from preclinical to… CONTINUE READING


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