Potential therapeutic efficacy of inhibitors of human phospholipase A2 in septic shock

@article{Vadas1986PotentialTE,
  title={Potential therapeutic efficacy of inhibitors of human phospholipase A2 in septic shock},
  author={PhD. P. Vadas and Eva Stefanski and Waldemar Pruzanski},
  journal={Agents and Actions},
  year={1986},
  volume={19},
  pages={194-202}
}
Soluble phospholipase A2 has been implicated in the pathogenesis of local and systemic inflammatory reactions. Elevated levels of circulating phospholipase A2 (PLA2) correlate with the severity of circulatory collapse and pulmonary dysfunction in gram-negative septic shock. Characterization of septic shock serum PLA2 revealed a calcium-dependent enzyme with… CONTINUE READING