Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.

@article{Miyashita2009PotentialTE,
  title={Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.},
  author={Katsuyoshi Miyashita and Kazuyoshi Kawakami and Mitsutoshi Nakada and W. Mai and Abbas Shakoori and Hironori Fujisawa and Yutaka Hayashi and Jun-ichiro Hamada and Toshinari Minamoto},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 3},
  pages={
          887-97
        }
}
PURPOSE Glioblastoma represents the malignant brain tumor that is most refractory to treatment and in which the identification of molecular target(s) is urgently required. We investigated the expression, activity, and putative pathologic role of glycogen synthase kinase 3beta (GSK3beta), an emerging therapeutic target for neurodegenerative diseases, in human glioblastoma. EXPERIMENTAL DESIGN The active fraction of GSK3beta that is phosphorylated at the tyrosine 216 residue (pGSK3betaY216) was… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

An organometallic kinase inhibitor pharmacologically activates p 53 and induces apoptosis in human melanoma cells

M Kunnimalaiyaan, AM Vaccaro, MA Ndiaye, H Chen
  • Cancer Res
  • 2007

Glycogen synthase kinase - 3 ( GSK 3 ) : inflammation , diseases , and therapeutics

RS Jope, GV Johnson
  • Neurochem Res
  • 2007

PTEN is destabilized by phosphorylation onThr 366

LD Mayo, JE Dixon, DL Durden, NK Tonks, DB Donner
  • BiochemJ
  • 2007

Detection of active fraction of GSK 3 h in cancer cells by nonradioi - sotopic in vitro kinase assay

RV Bhat, ShanleyJ, MP Correll
  • Oncology
  • 2006

Glycogen synthase kinase - 3 h positively regulates the proliferation of human ovarian cancer cells

KC Yao, KondoY KomataT, KanzawaT, S Kondo, IM Germano
  • Cell Res
  • 2006

Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases.

  • Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • 2006

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