Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis.

@article{Yacila2014PotentialTD,
  title={Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis.},
  author={G Yacila and Youssef Sari},
  journal={Current medicinal chemistry},
  year={2014},
  volume={21 31},
  pages={
          3583-93
        }
}
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder caused by damage of motoneurons leading to paralysis state and long term disability. Riluzole is currently the only FDA-approved drug for the treatment of ALS. The proposed mechanisms of ALS include glutamate excitotoxicity, oxidative stress, mitochondrial dysfunction, protein aggregation, SOD1 accumulations, and neuronal death. In this review, we discuss potential biomarkers for the identification of patients with ALS. We… CONTINUE READING
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