Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair.

Abstract

The restoration of damaged articular cartilage is a long-pursued goal in regenerative medicine. Chondrocyte-specific differentiation of mesenchymal stem cells (MSCs) may be an effective means of repairing damaged cartilage. We identified small molecule 6 with sulfonamide as an agent that promotes specific chondrogenic differentiation of human adipose… (More)
DOI: 10.1016/j.bmcl.2016.08.069

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