Potential surrogate endpoints in cancer research--some considerations and examples.

@article{Duffy2011PotentialSE,
  title={Potential surrogate endpoints in cancer research--some considerations and examples.},
  author={S W Duffy and F. P. Treasure},
  journal={Pharmaceutical statistics},
  year={2011},
  volume={10 1},
  pages={34-9}
}
We present an introductory survey of the use of surrogates in cancer research, in particular in clinical trials. The concept of a surrogate endpoint is introduced and contrasted with that of a biomarker. It is emphasized that a surrogate endpoint is not universal for an indication but will depend on the mechanism of treatment. We discuss the measures of… CONTINUE READING