Potential structural and functional biomarkers of upper motor neuron dysfunction in ALS.

@article{Grieve2015PotentialSA,
  title={Potential structural and functional biomarkers of upper motor neuron dysfunction in ALS.},
  author={Stuart M. Grieve and Parvathi Menon and Mayuresh S. Korgaonkar and Lavier Gomes and Sheryl L. Foster and Matthew C Kiernan and Steve Vucic},
  journal={Amyotrophic lateral sclerosis & frontotemporal degeneration},
  year={2015},
  volume={17 1-2},
  pages={
          85-92
        }
}
Assessment of upper motor neuron (UMN) function in amyotrophic lateral sclerosis (ALS) remains clinically based. Given the potential difficulties in identifying UMN signs, objective biomarkers of UMN dysfunction are important. Consequently, the present study assessed utility of cortical thickness analysis combined with threshold tracking transcranial magnetic stimulation (TMS) as biomakers of UMN dysfunction in ALS. Cortical thickness analysis and threshold tracking TMS studies were undertaken… CONTINUE READING

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Assessment of the upper motor neuron in amyotrophic lateral sclerosis

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