Potential sources of intrinsic optical signals imaged in live brain slices.

@article{Andrew1999PotentialSO,
  title={Potential sources of intrinsic optical signals imaged in live brain slices.},
  author={R. David Andrew and Cathryn R. Jarvis and Amjad Obeidat},
  journal={Methods},
  year={1999},
  volume={18 2},
  pages={185-96, 179}
}
Changes in how light is absorbed or scattered in biological tissue are termed intrinsic optical signals (IOSs). Imaging IOSs in the submerged brain slice preparation provides insight into brain activity if it involves significant water movement between intracellular and extracellular compartments. This includes responses to osmotic imbalance, excitotoxic glutamate agonists, and oxygen/glucose deprivation, the latter leading to spreading depression. There are several misconceptions regarding… CONTINUE READING