Potential sources of increased iron in the substantia nigra of parkinsonian patients.

  title={Potential sources of increased iron in the substantia nigra of parkinsonian patients.},
  author={Manfred Gerlach and Kay L Double and Moussa B. H. Youdim and Peter Franz Riederer},
  journal={Journal of neural transmission. Supplementum},
Histopathological, biochemical and in vivo brain imaging techniques, such as magnetic resonance imaging and transcranial sonography, revealed a consistent increase of substantia nigra (SN) iron in Parkinson's disease (PD). Increased iron deposits in the SN may have genetic and non-genetic causes. There are several rare movement disorders associated with neurodegeneration, and genetic abnormalities in iron regulation resulting in iron deposition in the brain. Non-genetic causes of increased SN… CONTINUE READING
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