Potential sites of action of TNPA: a dopamine-2 receptor agonist.

  title={Potential sites of action of TNPA: a dopamine-2 receptor agonist.},
  author={Edward P. F. Chu and T Ch Chu and David E. Potter},
  journal={Experimental eye research},
  volume={69 6},
The purpose of this study was to correlate potential mechanisms with site(s) of action for TNPA-induced ocular hypotension. In response to R(-)-2, 10, 11-trihydroxy-N-propyl-noraporphine hydrobromide (TNPA, 75 microg), a D2 dopamine receptor agonist, the intraocular pressure decreased by 4.5 and 8 mm Hg at 1 and 2 hr, respectively, as measured by pneumatonometry. The levels of norepinephrine in aqueous humor, as determined by high performance liquid chromatography with electrochemical detection… CONTINUE READING

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