Potential significance of phenotypic heterogeneity of focal lesions at different stages in hepatocarcinogenesis.

@article{Enzmann1987PotentialSO,
  title={Potential significance of phenotypic heterogeneity of focal lesions at different stages in hepatocarcinogenesis.},
  author={Harald H. Enzmann and Peter Bannasch},
  journal={Carcinogenesis},
  year={1987},
  volume={8 11},
  pages={1607-12}
}
In this study we used morphometric methods to investigate the number, size and phenotype of foci of altered hepatocytes in male rats after limited (7 weeks) oral administration of N-nitrosomorpholine (stop-model). We found a chronological sequence from clear and eosinophilic cell foci (CCF and ECF) of early appearance followed by intermediate and mixed (MCF) and basophilic cell foci (BCF). Eventually, neoplastic nodules (NN) and hepatocellular carcinomas (HC) developed. The animals killed first… CONTINUE READING
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