• DOI:10.1016/j.neubiorev.2013.03.018
Corpus ID: 1725139

Potential roles of zinc in the pathophysiology and treatment of major depressive disorder

@article{Swardfager2013PotentialRO,
  title={Potential roles of zinc in the pathophysiology and treatment of major depressive disorder},
  author={W. Swardfager and N. Herrmann and R. McIntyre and Graham Mazereeuw and K. Lanct{\^o}t},
  journal={Neuroscience & Biobehavioral Reviews},
  year={2013},
  volume={37},
  pages={911-929}
}

• W. Swardfager, N. Herrmann, +2 authors K. Lanctôt
• Published 2013
• Psychology, Medicine
• Neuroscience & Biobehavioral Reviews

Incomplete response to monoaminergic antidepressants in major depressive disorder (MDD), and the phenomenon of neuroprogression, suggests a need for additional pathophysiological markers and pharmacological targets. Neuronal zinc is concentrated exclusively within glutamatergic neurons, acting as an allosteric modulator of the N-methyl D-aspartate and other receptors that regulate excitatory neurotransmission and neuroplasticity. Zinc-containing neurons form extensive associational circuitry… Expand

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