Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

@article{Zhang2017PotentialRO,
  title={Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties},
  author={Xin-Yu Zhang and A. Elfarra},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2017},
  volume={13},
  pages={513 - 524}
}
ABSTRACT Introduction: Adverse drug reactions (ADRs) pose a significant health problem and are generally attributed to reactive metabolites. Olefinic moieties in drugs can undergo cytochrome P450-mediated bioactivation to produce reactive metabolites but myeloperoxidase (MPO)-mediated bioactivation of these moieties has not been reported. Thus, small molecules of alkene hydrocarbons are used as model compounds to characterize the MPO-mediated metabolism. Areas covered: The authors focus on MPO… Expand
Looking Back at the Early Stages of Redox Biology
Advances in nanomedicine for cancer starvation therapy

References

SHOWING 1-10 OF 114 REFERENCES
Role of reactive metabolites in the circulation in extrahepatic toxicity
CYP2E1-dependent benzene toxicity: the role of extrahepatic benzene metabolism
Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome.
Alcohol dehydrogenase- and rat liver cytosol-dependent bioactivation of 1-chloro-2-hydroxy-3-butene to 1-chloro-3-buten-2-one, a bifunctional alkylating agent.
Minimising the potential for metabolic activation in drug discovery
1,3-Butadiene: I. Review of metabolism and the implications to human health risk assessment
Bioactivation potential of thiophene-containing drugs.
...
1
2
3
4
5
...