Potential roles for tumour necrosis factor alpha during embryonic development.

  title={Potential roles for tumour necrosis factor alpha during embryonic development.},
  author={Michael A. Wride and Esmond J. Sanders},
  journal={Anatomy and embryology},
  volume={191 1},
This paper reviews the evidence indicating possible roles for tumour necrosis factor-alpha (TNF alpha) in development. It is proposed that TNF alpha may have essentially three major roles during embryonic development, which may be analogous to its roles in the immune system and during inflammation: a role in programmed cell death; a role as a cellular growth and differentiation factor; and also a role in the remodelling of extracellular matrix, and the regulation of cell adhesion molecules and… CONTINUE READING
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