Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease.

@article{Herrmann2008PotentialRO,
  title={Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease.},
  author={Joerg Herrmann and Sandra M Soares and Lilach Orly Lerman and Amir Lerman},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={51 21},
  pages={2003-10}
}
Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper… CONTINUE READING
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