Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection.

@article{Luan2012PotentialRO,
  title={Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection.},
  author={Yifu Luan and Jianqi Ju and Liping Luo and Zhongming Zhang and Jiao Wang and D-M Zhu and Li-Hong Cheng and S-Y Zhang and Liling Chen and F-S Wang and Shengdian Wang},
  journal={Journal of viral hepatitis},
  year={2012},
  volume={19 1},
  pages={
          23-31
        }
}
Immune-mediated mechanisms have been implicated in liver pathogenesis and subsequent progression in hepatitis B virus (HBV) infection. Costimulatory molecules, the important regulators of immune responses, participate in the regulation of liver pathology in HBV infection. However, the role of B7-H3 (CD276, a new member of B7 family) in this process has not been investigated. In this study, we detected abundant soluble B7-H3 (sB7-H3) in the plasma of patients with chronic HBV infections. The… CONTINUE READING
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