Potential role of rhIGF-I/IGFBP-3 in maintaining skeletal mass in space.


Bone loss during space flight may be induced by decreased activity of bone formation. To explore a new method for the bone loss in microgravity, the effects of insulin-like growth factor I (IGF-I), a potent stimulator for osteoblast activities, were studied in in vitro and in vivo system. The complex of IGF-I and its specific binding protein, IGFBP-3, may stimulate the osteoblastic activities via prolonged serum half life and increased cellular association of IGF-I. In an ovariectomy combined with neurectomy model, this complex stimulated bone turnover. IGF-I/IGFBP-3 may be a candidate for the treatment of bone loss induced by the microgravity.


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@article{Tanaka1998PotentialRO, title={Potential role of rhIGF-I/IGFBP-3 in maintaining skeletal mass in space.}, author={Hiroyuki Tanaka and Tadashi Moriwake and Yasuji Matsuoka and Tadashi Nakamura and Yutaka Seino}, journal={Bone}, year={1998}, volume={22 5 Suppl}, pages={145S-147S} }