Potential role of poly(ADP-ribose) polymerase activation in the pathogenesis of experimental left varicocele.

@article{Tekcan2012PotentialRO,
  title={Potential role of poly(ADP-ribose) polymerase activation in the pathogenesis of experimental left varicocele.},
  author={Merih Tekcan and Ismail Turker Koksal and Arda Taşatargil and Omer Kutlu and Ece Gungor and C Celik-Ozenci},
  journal={Journal of andrology},
  year={2012},
  volume={33 1},
  pages={122-32}
}
The aim of this study was to evaluate whether the poly(adenosine diphosphate[ADP]-ribose) polymerase (PARP) pathway is activated by experimental left varicocele. Rats underwent partial ligation of the left renal vein to induce experimental varicocele, and left testes were analyzed 13 weeks after surgery. Tubule degeneration was evaluated by Johnsen score. Expression of 4-hydroxy-2-nonenal (4-HNE)-modified proteins, PARP-1, and poly(-ADP-ribose) (PAR) was detected by immunohistochemistry and… CONTINUE READING