Potential role of p62 in tumor development.

@article{Komatsu2011PotentialRO,
  title={Potential role of p62 in tumor development.},
  author={M. Asaliaru Komatsu},
  journal={Autophagy},
  year={2011},
  volume={7 9},
  pages={1088-90}
}
p62 is a ubiquitously expressed cellular protein conserved in metazoa but not in plants and fungi, and is known as one of the selective substrates for autophagy. This protein is localized at the autophagosome formation site and directly interacts with LC3, an autophagosome-localizing protein, and it is incorporated subsequently into the autophagosome and finally degraded. Impaired autophagy is accompanied by the accumulation of p62, followed by the formation of aggregates positive for p62 and… CONTINUE READING

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