Potential role of oxidized lipids and lipoproteins in antioxidant defense.

  title={Potential role of oxidized lipids and lipoproteins in antioxidant defense.},
  author={Sampath Parthasarathy and Nalini Santanam and Sumathi Ramachandran and Olivier Meilhac},
  journal={Free radical research},
  volume={33 3},
The atherogenic oxidative modification of low-density lipoprotein is suggested to occur in the aortic intima. There is reasonable evidence to suggest that antioxidants might be beneficial in preventing or retarding the progression of atherosclerosis. Exercise, estrogens, and substitution of polyunsaturated fat for saturated fat are beneficial in the prevention of atherosclerosis. Yet, paradoxically, they are capable of inducing an oxidative stress. To reconcile with this paradox, we postulate… CONTINUE READING

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