Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos.

@article{Takada2009PotentialRO,
  title={Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos.},
  author={Shuji Takada and Eugene Berezikov and Young Lim Choi and Yoshihiro Yamashita and Hiroyuki Mano},
  journal={RNA},
  year={2009},
  volume={15 8},
  pages={1507-14}
}
MicroRNAs (miRNAs) are a recently discovered class of small noncoding RNAs and are implicated in an increasing number of biological processes. To examine whether miRNAs might contribute to sexual differentiation, we performed expression profiling of miRNAs in mouse embryonic gonads with the use of a highly sensitive cloning method, mRAP. Our profiling data revealed substantial differences in the miRNA repertoire between male and female gonads at embryonic (E) day 13.5 (E13.5), suggesting that… CONTINUE READING

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