Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

@article{Park2001PotentialRO,
  title={Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro},
  author={H Park and Hyuck-moon Kwon and Hyun Joung Lim and Bum Kee Hong and Jae Hyun Lee and Byoung Eun Park and Yang Soo Jang and Seung Yun Cho and Hyun-Seung Kim},
  journal={Experimental & Molecular Medicine},
  year={2001},
  volume={33},
  pages={95-102}
}
Leptin, the product of ob gene, is an endocrine hormone that regulates adipose tissue mass. Recently, leptin has been found to generate a growth signal involving a tyrosine kinase-dependent intracellular pathway and promote angiogenic processes via activation of leptin receptor (Ob-R) in endothelial cells. However, it is not clear how leptin functions to promote multi-step processes involved in the neovascularization at the atherosclerotic plaque. We have examined the expression of matrix… CONTINUE READING