Potential role of interleukin-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cells.

@article{Iannello2009PotentialRO,
  title={Potential role of interleukin-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cells.},
  author={Alexandre Iannello and Suzanne Samarani and Olfa D{\'e}bbeche and Rasheed Ahmad and Mohamed-Rachid Boulassel and C{\'e}cile Tremblay and Emil Toma and Jean-Pierre Routy and Ali Ahmad},
  journal={Journal of virology},
  year={2009},
  volume={83 12},
  pages={
          5999-6010
        }
}
We had shown earlier that the concentrations of circulating interleukin-18 (IL-18) are increased significantly in human immunodeficiency virus (HIV)-infected persons compared to HIV-seronegative healthy subjects. In the present study, we investigated the consequences of these elevated levels of IL-18 on natural killer (NK) cells and the immunopathogenesis of AIDS. We show here an inverse correlation between IL-18 concentrations and absolute numbers of various subsets of NK cells in infected… CONTINUE READING

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