Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma

  title={Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma},
  author={Catherine M Hawrylowicz and Anne O'Garra},
  journal={Nature Reviews Immunology},
Allergic diseases are caused by aberrant T-helper-2 immune responses in susceptible individuals. Both naturally occurring CD4+CD25+ regulatory T cells and inducible populations of antigen-specific interleukin-10-secreting regulatory T cells inhibit these inappropriate immune responses in experimental models. This article discusses the evidence that regulatory T-cell function might be impaired in allergic and asthmatic disease and that certain therapeutic regimens might function, at least in… CONTINUE READING
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