Potential role of high mobility group box protein 1 and intermittent PTH (1–34) in periodontal tissue repair following orthodontic tooth movement in rats

@article{Wolf2012PotentialRO,
  title={Potential role of high mobility group box protein 1 and intermittent PTH (1–34) in periodontal tissue repair following orthodontic tooth movement in rats},
  author={M Wolf and Stefan Lossd{\"o}rfer and Nuersailike Abuduwali and Andreas J{\"a}ger},
  journal={Clinical Oral Investigations},
  year={2012},
  volume={17},
  pages={989-997}
}
Recent studies indicate that high mobility group box protein 1 (HMGB1) can be released by necrotic and damaged cells and functions as an alarmin that is recognized by the innate immune system. Little is known about the role of HMGB1 within the periodontal ligament (PDL). Therefore, we examined HMGB1 expression by PDL cells in vitro and compared the findings to an in vivo model of orthodontically induced tooth root resorption. In addition, we addressed the question of whether a potentially… CONTINUE READING
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