Potential role of group X secretory phospholipase A(2) in cyclooxygenase-2-dependent PGE(2) formation during colon tumorigenesis.

@article{Morioka2000PotentialRO,
  title={Potential role of group X secretory phospholipase A(2) in cyclooxygenase-2-dependent PGE(2) formation during colon tumorigenesis.},
  author={Yoko Morioka and Masahiko Ikeda and Akihiko Saiga and Nobuhiro Fujii and Yoshikazu Ishimoto and Hitoshi Arita and Kohji Hanasaki},
  journal={FEBS letters},
  year={2000},
  volume={487 2},
  pages={
          262-6
        }
}
Although the cyclooxygenase-2 (COX-2) pathway of the arachidonic acid cascade has been suggested to play an important role in colon carcinogenesis, there is little information concerning the identity of phospholipase A(2) (PLA(2)) involved in the arachidonic acid release in colon tumors. Here, we compared the potencies of three types of secretory PLA(2)s (group IB, IIA and X sPLA(2)s) for the arachidonic acid release from cultured human colon adenocarcinoma cells, and found that group X sPLA(2… CONTINUE READING

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