Potential role of gene-environment interactions in ion transport mechanisms in the etiology of renal cell cancer

@article{Deckers2016PotentialRO,
  title={Potential role of gene-environment interactions in ion transport mechanisms in the etiology of renal cell cancer},
  author={I. Deckers and P. A. van den Brandt and M. van Engeland and F. V. van Schooten and R. Godschalk and A. Keszei and J. Hogervorst and L. Schouten},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
We investigated the ion transport mechanism (ITM) in renal cell cancer (RCC) etiology using gene-environment interactions between candidate single nucleotide polymorphisms (SNPs) and associated environmental factors, including dietary intakes of sodium, potassium and fluid, hypertension and diuretic medication. A literature-based selection of 13 SNPs in ten ITM genes were successfully genotyped in toenail DNA of 3,048 subcohort members and 419 RCC cases from the Netherlands Cohort Study. Diet… Expand

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