Potential role of diabetes mellitus in the progression of cirrhosis to hepatocellular carcinoma: a cross-sectional case-control study from Chinese patients with HBV infection.

@article{Gao2013PotentialRO,
  title={Potential role of diabetes mellitus in the progression of cirrhosis to hepatocellular carcinoma: a cross-sectional case-control study from Chinese patients with HBV infection.},
  author={Chun Gao and Long Fang and Hong-chuan Zhao and Jingtao Li and S. Yao},
  journal={Hepatobiliary \& pancreatic diseases international : HBPD INT},
  year={2013},
  volume={12 4},
  pages={
          385-93
        }
}
  • Chun Gao, Long Fang, +2 authors S. Yao
  • Published 2013
  • Medicine
  • Hepatobiliary & pancreatic diseases international : HBPD INT
BACKGROUND Diabetes mellitus (DM) is regarded as a new risk factor for hepatocellular carcinoma (HCC), but few studies have focused on the potential role of DM in the progression of cirrhosis to HCC as well as in patients with simple HBV infection. METHODS A cohort of 1028 patients, treated at our hospital and with a hospital discharge diagnosis of HCC and/or cirrhosis, was screened. Among them, 558 were diagnosed with chronic HBV infection and 370 were analyzed statistically according to the… Expand
Diabetes Mellitus is a Risk Factor for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Virus Infection in China
  • Xu Li, H. Xu, Pujun Gao
  • Medicine
  • Medical science monitor : international medical journal of experimental and clinical research
  • 2018
TLDR
In a Chinese population with chronic HBV infection, DM increased the risk of HCC, as did cigarette smoking and high levels of HBV DNA, and screened patients with known risk factors for HCC to prevent tumor progression. Expand
Association Between Hepatocellular Carcinoma and Type 2 Diabetes Mellitus in Chinese Hepatitis B Virus Cirrhosis Patients: A Case-Control Study
TLDR
T2DM may not be a risk factor for the presence of HCC in HBV cirrhosis, and platelet, alanine aminotransferase, and γ-glutamine transferase were associated with the risk of H CC. Expand
Diabetes mellitus and changes of peripheral blood cells in Chinese patients with hepatocellular carcinoma
Background: Diabetes mellitus (DM) has been identified as a new risk factor for hepatocellular carcinoma (HCC) that is also associated with changes of peripheral blood cells. However, no informationExpand
Editorial: diabetes and its association with hepatocellular carcinoma in chronic hepatitis B
TLDR
Overall this study demonstrates the importance of addressing modifiable metabolic risk factors in patients with CHB, and the impact of anti-diabetic regimen should be assessed as data has suggested decreased risk of HCC and liver related mortality in patients on metformin. Expand
Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus
TLDR
SBP level was increased in HCC patients with diabetes mellitus and the relationship between SBP and DM was supported by most (10/14) of the subgroup analyses. Expand
Risk factors for the development of hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) infection: a systematic review and meta-analysis
TLDR
In adults with chronic HBV infection, diabetes mellitus is a significant risk factor for HCC, but further investigation of how antidiabetic drug use and glycaemic control influence this association is needed. Expand
Risk factors for the development of hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) infection: a systematic review and meta‐analysis
TLDR
In adults with chronic HBV infection, DM is a significant risk factor for HCC, but further investigation of the influence of antidiabetic drug use and glycaemic control on this association is needed. Expand
Diabetes Mellitus and Risk of Hepatocellular Carcinoma
TLDR
The role of potential pathways that could account for the development of HCC with different etiologies in the presence of DM are evaluated and the potential effect of other factors such as type and dosage of antidiabetic medicines and duration of DM on HCC risk is discussed. Expand
Editorial: diabetes and its association with hepatocellular carcinoma in chronic hepatitis B – authors’ reply
TLDR
This review concludes that a randomized trial to examine the efficacy of metformin in improving survival in cirrhosis: pleiotropic effects hypothesis and the impact of type 2 diabetes on the development of hepatocellular carcinoma in different viral hepatitis statuses is warranted. Expand
Hepatocellular Carcinoma: the Impact of NAFLD
TLDR
Long-term outcomes appear to be similar for NASH-related HCC and HCC due to other etiologies, but research on preventive strategies, screening programs for patients with NASH without cirrhosis but at high risk of HCC development, and new therapeutic strategies are warranted. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 32 REFERENCES
Diabetes mellitus and hepatocellular carcinoma: comparison of Chinese patients with and without HBV-related cirrhosis.
TLDR
DM was found to be the sole independent factor associated with HCC in patients with HBV-related cirrhosis, compared with those without cirrhotic disease, after other known concomitant diseases were excluded. Expand
The role of diabetes in hepatocellular carcinoma: a case-control study among United States veterans
TLDR
DM increased the risk of PLC only in the presence of other risk factors such as hepatitis C or B or alcoholic cirrhosis, and without markers of chronic liver disease the adjusted OR for diabetes and PLC was not significantly increased. Expand
Differential Mechanism and Prognostic Impact of Diabetes Mellitus on Patients with Hepatocellular Carcinoma Undergoing Surgical and Nonsurgical Treatment
TLDR
There is a selective mechanism and prognostic impact of DM on HCC patients undergoing surgical and nonsurgical therapy depending on treatment strategy and under the influence of tumoral and cirrhosis factors. Expand
Type 2 diabetes and hepatocellular carcinoma: A cohort study in high prevalence area of hepatitis virus infection
TLDR
In an area with a high prevalence of hepatitis virus infection, type 2 diabetes increases the risk of developing HCC in those who are HCV negative or have a high level of total cholesterol. Expand
Neither Diabetes Mellitus nor Overweight Is a Risk Factor for Hepatocellular Carcinoma in a Dual HBV and HCV Endemic Area: Community Cross-Sectional and Case–Control Studies
TLDR
Neither DM nor overweight was a risk factor for HCC in a dual HBV and HCV endemic area of southern Taiwan, and only thrombocytopenia and high alanine transaminase (ALT) levels were shown to be independent risk factors. Expand
Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus
TLDR
For patients with chronic hepatitis C and advanced cirrhosis, diabetes mellitus increases the risk of developing HCC. Expand
Effect of alcohol, cigarette smoking, and diabetes on occurrence of hepatocellular carcinoma in patients with transfusion-acquired hepatitis C virus infection who develop cirrhosis
TLDR
Diabetes, smoking, and alcohol drinking were not independently related to the risk of developing hepatocellular carcinoma in hepatitis C virus-related liver cirrhosis. Expand
Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma.
TLDR
Among men with diabetes, the risk of chronic nonalcoholic liver disease and hepatocellular carcinoma is doubled, independent of alcoholic liver disease, viral hepatitis, or demographic features. Expand
Excess risk of primary liver cancer in patients with diabetes mellitus.
TLDR
It is suggested that patients with diabetes are at increased risk of developing primary liver cancer and perhaps cancers of the biliary tract. Expand
Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study
TLDR
Findings from this population based study suggest that diabetes is an independent risk factor for HCC, regardless of the presence of other major HCC risk factors. Expand
...
1
2
3
4
...