Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF).

@article{Gao1998PotentialRO,
  title={Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF).},
  author={Yue Hua Gao and Toshimasa Shinki and Tomoyuki Yuasa and H Kataoka-Enomoto and Toshihisa Komori and Tatsuo Suda and Akira Yamaguchi},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={252 3},
  pages={697-702}
}
The role of Cbfa1 (core binding factor alpha1), an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis was investigated in vitro and in vivo using Cbfa1-deficient calvarial cells and mice. Co-cultures of calvarial cells isolated from embryos with three different Cbfa1 genotypes (Cbfa1+/+, Cbfa1+/- and Cbfa1-/-) and normal spleen cells generated TRAP-positive multinucleated osteoclast-like cells (OCLs) in response to 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH… CONTINUE READING
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