Potential role of bromelain in clinical and therapeutic applications.

  title={Potential role of bromelain in clinical and therapeutic applications.},
  author={Vidhya Rathnavelu and Noorjahan Banu Mohamed Alitheen and Subramaniam Sohila and Samikannu Kanagesan and Rajendran Ramesh},
  journal={Biomedical reports},
  volume={5 3},
Pineapple has been used as part of traditional folk medicine since ancient times and it continues to be present in various herbal preparations. Bromelain is a complex mixture of protease extracted from the fruit or stem of the pineapple plant. Although the complete molecular mechanism of action of bromelain has not been completely identified, bromelain gained universal acceptability as a phytotherapeutic agent due to its history of safe use and lack of side effects. Bromelain is widely… 
Beneficial Properties of Bromelain
It is supposed that the anti-viral, anti-inflammatory, cardioprotective and anti-coagulatory activity of bromelain may become a complementary therapy for COVID-19 and post-CO VID-19 patients.
Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (Ananas comosus) and Their Possible Therapeutic and Clinical Effects. A Summary
The potential of bromelain’s important characteristics and meditative and therapeutic effects, along with the possible mechanism of action are concentrated on.
Anti-inflammatory properties of a proprietary bromelain extract (Bromeyal™) after in vitro simulated gastrointestinal digestion
The capability of bromelain to reduce an inflammatory stimulus is demonstrated by reproducing its exposure to the gastro-enteric environment in vitro and assaying its effect in human cell lines derived from stomach, intestinal, and chondrocytes.
A comprehensive overview on the anti-inflammatory, antitumor, and ferroptosis functions of bromelain: an emerging cysteine protease
Identification of molecular targets and crucial signalling pathways that bromelain regulates suggest it genuinely prospects for combating cancer and mitigation of chemotherapy or radiotherapy mediated side effects.
Herbal Preparation (Bromelain, Papain, Curcuma, Black Pepper) Enhances Mineralization and Reduces Glucocorticoid-Induced Osteoporosis in Zebrafish
Evaluating whether curcuma-bromelain-papain-pepper herbal preparation administered in embryos and adult fish is capable of promoting bone wellness in physiological and osteoporotic conditions indicated CHP as a potential integrative antioxidant therapy in human bone-loss diseases.
Natural actives for wound healing: A review
Traditional used natural actives for wound healing are reviewed, highlighting their characteristics and mode of action and how they can be used for cutaneous wound treatment.
Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction
The first phytochemical and biological characterization in treatment of adrenocortical carcinoma cells (H295R) of extracts from Nidularium procerum constitutes new data on the Bromeliaceae family, which should be better exploited to the production of new phytomedicines for pharmacological uses.
Evaluation of the Effect of Zinc, Quercetin, Bromelain and Vitamin C on COVID-19 Patients
Quercetin 800 mg, bromelain 165 mg, zinc acetate 50 mg and ascorbic acid 1 g once daily supplements were safe for patients infected with SARS-CoV-2 and may prevent poor prognosis and Randomized clinical trials needed in the future to ensure the efficacy of quercet in, bemelain, zinc and vitamin c combination.
Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
The results demonstrated the chondroprotective effects of bromelain on cartilage degradation and the downregulation of inflammatory cytokine expression in TNF-α–induced synovial fibroblasts by suppressing NF-κB and MAPK signaling.


Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update.
Bromelain: biochemistry, pharmacology and medical use
  • H. Maurer
  • Medicine, Biology
    Cellular and Molecular Life Sciences CMLS
  • 2001
Whether bromelain will gain wide acceptance as a drug that inhibits platelet aggregation, is antimetastatic and facilitates skin debridement, among other indications, will be determined by further clinical trials.
Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies
The mechanism of its putative therapeutic actions, those clinical trials that have assessed its use in osteoarthritis to date, as well as considering the safety implications of this supplement for osteoartritis and reviewing the evidence to date regarding the dosage for treating this condition are reviewed.
Possible involvement of eicosanoids in the pharmacological action of bromelain.
Results seem to indicate an interference of bromelain with arachidonic acid cascade, which deserves further investigation to be better assessed.
In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain.
Bromelain significantly reduced the number of lung metastasis induced by LLC transplantation, as observed with 5-FU, and the unchanged tumor progression in the metastatic model suggests that the antimetastatic action results from a mechanism independent of the primary antitumoral effect.
On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects.
Bromelain, a standardized complex of proteases from the pineapple plant, is absorbed unchanged from the intestine of animals at a rate of 40%; in animal experiments it was found to have primarily
Therapy with Proteolytic Enzymes in Rheumatic Disorders
The results of various studies in patients with rheumatic diseases suggest that oral therapy with proteolytic enzymes produces certain analgesic and anti-inflammatory effects, however, the results are often inconsistent.
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.